IGCSE Biology 0610 — October-November 2025 Past Papers, Topics & Exam Tips
The Cambridge IGCSE Biology (0610) October-November 2025 session consisted of 6 papers across 18 variants, covering 27 syllabus topics across all papers. This page links to every question paper, mark scheme, grade threshold and session feedback document released by Cambridge for this session, together with a topic-level breakdown of what was tested and topic-matched exam tips in our own voice.
Study Resources for Biology
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Jump straight to the topics this session tested most:
0610 October-November 2025 Papers
0610 Paper 1 - Multiple Choice (Core)
45 min • 40 marks
Tests broad syllabus knowledge with 40 questions. Each question has four options (A-D). Core tier paper.
0610 Paper 2 - Multiple Choice (Extended)
45 min • 40 marks
Extended tier multiple choice with more challenging questions covering the full syllabus. 40 questions, 45 minutes.
0610 Paper 3 - Theory (Core)
1 hr 15 min • 80 marks
Structured and free-response questions testing understanding and application. Core tier, grades available C-G.
View syllabus topics tested in Paper 3 (8 topics, 80 marks total)
This 0610 Paper 3 from October-November 2025 tests 8 different syllabus topics. The highest-weighted topic is Population size (Organisms and their environment) worth 14 marks out of 80 total marks. Other significant topics include Concept and use of a classification system (13 marks) and Biological molecules (11 marks).
Mark distribution by topic:
Understanding which topics carry the most marks helps you prioritize your Biology revision. Practice questions from high-mark topics like Population size to maximize your score.
0610 Paper 4 - Theory (Extended)
1 hr 15 min • 80 marks
Extended tier theory paper with more demanding questions. Full grade range A*-G available with this paper.
View syllabus topics tested in Paper 4 (6 topics, 80 marks total)
This 0610 Paper 4 from October-November 2025 tests 6 different syllabus topics. The highest-weighted topic is Pollution (Human influences on ecosystems) worth 19 marks out of 80 total marks. Other significant topics include Sexual reproduction in plants (18 marks) and Circulatory system (15 marks).
Mark distribution by topic:
Understanding which topics carry the most marks helps you prioritize your Biology revision. Practice questions from high-mark topics like Pollution to maximize your score.
0610 Paper 5 - Practical Test
1 hr 15 min • 40 marks
Tests practical skills including planning experiments, recording data, and drawing conclusions from results.
View syllabus topics tested in Paper 5 (2 topics, 40 marks total)
This 0610 Paper 5 from October-November 2025 tests 2 different syllabus topics. The highest-weighted topic is Xylem and phloem (Transport in plants) worth 26 marks out of 40 total marks. Other significant topics include Biological molecules (8 marks)
Mark distribution by topic:
Understanding which topics carry the most marks helps you prioritize your Biology revision. Practice questions from high-mark topics like Xylem and phloem to maximize your score.
0610 Paper 6 - Alternative to Practical
1 hr • 40 marks
Written paper testing practical skills through questions about experimental methods, data, and analysis.
View syllabus topics tested in Paper 6 (2 topics, 40 marks total)
This 0610 Paper 6 from October-November 2025 tests 2 different syllabus topics. The highest-weighted topic is Xylem and phloem (Transport in plants) worth 26 marks out of 40 total marks. Other significant topics include Enzymes (8 marks)
Mark distribution by topic:
Understanding which topics carry the most marks helps you prioritize your Biology revision. Practice questions from high-mark topics like Xylem and phloem to maximize your score.
Topic coverage in October-November 2025
Marks in this session were weighted unevenly across the 27 syllabus topics, with the heaviest emphasis on Xylem and phloem. Substantial weight also fell on Respiration and Cell structure and organisation , with Digestive system and Circulatory system rounding out the five most-tested areas. Together these five topics made up about 50% of the topic-level marks awarded in the October-November 2025 session — a useful signal for where to focus revision time. The full topic-by-paper breakdown is further down the page.
Exam tips for topics in October-November 2025
- → Respiration: Respiration is the process by which cells liberate energy from nutrient molecules.
- → Cell structure and organisation: Recall that the partially permeable membrane regulates traffic into and out of the cell; that's the cell surface membrane.
- → Digestive system: In your notes, make a chart of digestive processes ordered by location: mouth, then stomach, then small intestine.
- → Circulatory system: On a diagram, trace the full loop: heart → pulmonary artery → lungs → pulmonary vein → heart.
Other Resources
Additional materials to help you prepare and understand how exams are marked.
What was tested on each paper — 0610 October-November 2025
Here's which syllabus topics appeared in each of the 6 Biology 0610 papers in October-November 2025 and how the marks broke down. Focus your revision on the papers you're sitting — Papers 1, 3 and 5 or 6 for Core tier; Papers 2, 4 and 5 or 6 for Extended tier. Click any topic below to jump straight to our revision notes, or browse the full Biology 0610 revision guide →.
Paper 3 — Theory (Core) · 80 marks total
Tested 8 topics. The heaviest-weighted were Population size (14m), Concept and use of a classification system (13m), Biological molecules (11m), Nervous control in humans (9m), Enzymes (9m) and Nutrient cycles (9m), plus 2 other topics.
Paper 4 — Theory (Extended) · 80 marks total
Tested 6 topics. The heaviest-weighted were Pollution (19m), Sexual reproduction in plants (18m), Circulatory system (15m), Concept and use of a classification system (12m), Transpiration (11m) and Chromosomes, genes and proteins (5m).
Paper 6 — Alternative to Practical · 40 marks total
Tested 2 topics. The heaviest-weighted were Xylem and phloem (26m) and Enzymes (8m).
0610 October-November 2025 at a glance
- Papers: 6 (18 variants total)
- Topics covered: 27
- Highest-weighted topic: Xylem and phloem
- Grade thresholds: released by Cambridge (linked above)
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0610 Study Tips & FAQ
What are paper variants?
Cambridge releases multiple variants of each paper (e.g., Paper 11, 12, 13) to accommodate different time zones around the world and maintain exam security.
Which variant you sit is set by your school's administrative zone: in the November 2026 timetable, for 0610, Variant 1 is sat in Zones 1 and 2, Variant 2 in Zones 3 and 4, and Variant 3 in Zones 5 and 6. Which zones sit which variant differs from subject to subject, so ask your exams officer which zone your school is in.
All variants cover the same syllabus and have similar difficulty. Practice with any variant to prepare effectively for your exam.
How to use Mark Schemes effectively
Mark schemes show exactly how examiners award marks for each question. Understanding them helps you write answers that earn full marks.
Tips:
- Look for key words that must appear in your answer
- Note how many points are needed for each mark
- Check if units are required for the final mark
- Understand the difference between "state" (brief) and "explain" (detailed)
Understanding Grade Thresholds
Grade thresholds show the minimum marks needed for each grade. They vary each session based on paper difficulty — harder papers have lower thresholds.
November 2025, option BX (components 21, 41, 51), out of 200:
From the Cambridge grade threshold table, November 2025. Each option has its own thresholds: see every 0610 session.
How to use thresholds:
- Set realistic target marks based on your goal grade
- Track your practice paper scores against thresholds
- Remember: you don't need 100% for an A* — aim for consistency
- Compare thresholds across sessions to gauge difficulty trends
How is the topic breakdown calculated?
The "Topics Breakdown by Paper" section above shows which syllabus topics are tested in each paper and how many marks they carry. Here's how we calculate this:
Our methodology:
- Extract questions: We analyze each question paper (QP) and identify individual questions and their mark allocations (shown in square brackets, e.g., [3]).
- Match to syllabus: Each question is matched to the official Cambridge 0610 syllabus topics based on keywords, concepts, and question content.
- Sum marks per topic: For each paper, we add up the marks for all questions testing the same topic. For example, if Q1 (4 marks) and Q5b (3 marks) both test "Enzymes", that topic shows as "7 marks" for that paper.
Example: If Paper 3 shows "Photosynthesis - 13 marks", it means questions worth a total of 13 marks (out of the paper's 80 marks) tested the Photosynthesis topic from the Plant Nutrition unit of the syllabus.
How to use this: Look at the paper(s) you'll be taking (e.g., Papers 2, 4 and 5 or 6 for Extended tier). The topics with the highest marks in YOUR papers are where you should focus your revision. A topic worth 15 marks deserves more study time than one worth 3 marks.
Note: Our topic matching may be inaccurate for questions that span multiple topics. Use this as a guide alongside the official syllabus.
How to Use IGCSE Biology Past Papers
📝 Timed Practice
Complete papers under exam conditions. 0610 Paper 4 (Theory, Extended) is 1 hr 15 min - practice finishing within this time to build exam stamina.
✅ Self-Marking
Use the mark scheme to score your answers. Look for marking points you missed and understand what examiners expect in Biology responses.
🎯 Grade Targets
In November 2025, an A* in IGCSE Biology needed 162 to 164 out of 200 (81% to 82%) on the Extended options, depending on the option (Cambridge grade threshold table, November 2025). See the grade thresholds for every 0610 session.
Frequently Asked Questions
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What papers are available for IGCSE Biology 0610?
What is the difference between paper variants 11, 12, and 13?
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